Osteoarthritis is a progressive degenerative pathology of the joint, affecting millions of people worldwide. ADMAIORA aims, in the long-term, at increasing the healthy and active lifespan of people affected by osteoarthritis, by considerably slowing down or even stopping the degeneration process, thus delaying by several years or even avoiding surgical interventions for total joint replacement.
To make this challenging objective a reality, the project partners collaborate in the investigation of nanotechnologies, advanced materials, ultrasound stimulation, arthroscopic surgical tools, wearable braces and cloud platforms into a unique workflow. ADMAIORA explores the potential of smart nanocomposite materials and stem cells, in synergy with external physical stimuli (based on low-intensity ultrasound), for lowering inflammation and regenerating the cartilage tissue. Within the project time-frame (4 years), the target is to demonstrate the ground-breaking potential of such a regenerative approach, at a preclinical level.

The Project

ADMAIORA targets a ground-breaking paradigm that may revolutionize osteoarthritis treatment. Within the project time-frame (4 years), the target is to achieve a 60% reduction of degeneration in osteoarthritis animal models treated with the ADMAIORA technologies, with respect to control (untreated) ones, after 4 weeks, and a 90% reduction after 3 months. The project has already generated several interesting scientific results, as well as inventions protected by patents tha may turn, in the future, into industrially exploitable results.

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 The BioRobotics Institute, Scuola Superiore Sant’Anna, Italy
 Istituto Ortopedico Rizzoli, Italy
 Bar-Ilan University, Israel
 PlasmaChem Gmbh, Germany
 Image Guided Therapy SA, France
 Vimex, Poland
 H&D Wireless, Sweden